GSDMA antibody

Catalog Number:

31941

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BT40
NCBI Protein#: BC109197

Form of Antibody:

pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Storage/Stability:

Immunogen:

Fusion protein of human GSDMA

Purification:

Antigen affinity purification

Specificity/Sensitivity:

Applications:

WB, IHC

Background:

May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

References:

appl_detail:

WB dilution:1:500-1:2000
IHC dilution:1:100-1:200

Datasheet PDF