Product Datasheet  
GSDMA antibody  
Catalog Number: 31941  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9BT40
    NCBI Protein#: BC109197
  • Form of Antibody：  
  • pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein of human GSDMA
  • reactivity：  
  • Hu, Ms
  • appl_detail：  
  • WB dilution:1:500-1:2000
    IHC dilution:1:100-1:200
  • other_names：  
  • GSDM; FKSG9; GSDM1
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • Applications：  
  • WB, IHC
  • Background：  
  • May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).



 
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