CRACR2A antibody

Catalog Number:

31918

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BQ67
NCBI Protein#: BC004524

Form of Antibody:

pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Storage/Stability:

Immunogen:

Fusion protein of human CRACR2A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

Applications:

WB, IHC

Background:

Ca2+-binding protein that plays a key role in store-operated Ca2+?entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

References:

appl_detail:

WB dilution:1:500-1:2000
IHC dilution:1:50-1:300

Datasheet PDF