Product Datasheet  
CRACR2A antibody  
Catalog Number: 31918  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9BQ67
    NCBI Protein#: BC004524
  • Form of Antibody：  
  • pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein of human CRACR2A
  • reactivity：  
  • Hu
  • appl_detail：  
  • WB dilution:1:500-1:2000
    IHC dilution:1:50-1:300
  • other_names：  
  • EFCAB4B
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • Applications：  
  • WB, IHC
  • Background：  
  • Ca2+-binding protein that plays a key role in store-operated Ca2+?entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.



 
© Signalway Biotechnology All Rights Reserved.