cbx7 Antibody

Catalog Number:

31805

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O95931
NCBI Gene ID: 23492
NCBI mRNA#: NM_175709.4
NCBI Protein#:NP_783640.1

Form of Antibody:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

A synthesized peptide derived from human cbx7,corresponding to a region within N-terminal amino acids.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB IF

Background:

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

References:

appl_detail:

WB dilution: 1:500-1:2000

IF dilution: 1:100-1:500

Datasheet PDF