TDP1 Polyclonal Antibody

Catalog Number:

31402

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9NUW8
NCBI Gene ID:55775

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human TDP1 (NP_060789.2).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

IF

Background:

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).

References:

appl_detail:

IF 1:50 - 1:100

Datasheet PDF