Product Datasheet  
TDP1 Polyclonal Antibody  
Catalog Number: 31402  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:Q9NUW8
    NCBI Gene ID:55775
  • Form of Antibody：  
  • Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fusion protein of human TDP1 (NP_060789.2).
  • reactivity：  
  • Human
  • appl_detail：  
  • IF 1:50 - 1:100
  • other_names：  
  • TDP1; tyrosyl-DNA phosphodiesterase 1
  • Purification：  
  • Affinity purification
  • Specificity：  
  • Applications：  
  • IF
  • Background：  
  • The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).



 
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