PDX1 Antibody

Catalog Number:

31259

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8WXW3
Gene ID:10464

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide peptide corresponding to a region derived from 18-31 amino acids of human pancreatic and duodenal homeobox 1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PDX1 protein.

Applications:

ELISA WB IHC

Background:

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

References:

appl_detail:

Predicted MW: 31kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:15-1:50

Datasheet PDF