Product Datasheet  
PDX1 Antibody  
Catalog Number: 31259  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q8WXW3
    Gene ID:10464
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide peptide corresponding to a region derived from 18-31 amino acids of human pancreatic and duodenal homeobox 1
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 31kd
    ELISA: 1:2000-1:5000
    Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:15-1:50
  • other_names：  
  • pancreatic and duodenal homeobox 1, GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total PDX1 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).



 
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