KCNA1 Antibody

Catalog Number:

31226

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8N4F0
Gene ID:80341

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 460-472 amino acids of Human potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total KCNA1 protein.

Applications:

ELISA WB

Background:

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

References:

appl_detail:

Predicted MW: 56kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF