Product Datasheet  
KCNA1 Antibody  
Catalog Number: 31226  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q8N4F0
    Gene ID:80341
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 460-472 amino acids of Human potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 56kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:500-1:2000

  • other_names：  
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia), EA1, MK1, AEMK, HBK1, HUK1, MBK1, RBK1, KV1.1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total KCNA1 protein.
  • Applications：  
  • ELISA WB
  • Background：  

  • This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).




 
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