IL15RA Antibody

Catalog Number:

31223

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6ISS4
Gene ID:3904

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 250-264 amino acids of Human interleukin 15 receptor, alpha

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total IL15RA protein.

Applications:

ELISA WB

Background:

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.

References:

appl_detail:

Predicted MW: 28kd
ELISA: 1:1000-1:5000
Western blotting: 1:1000-1:5000

Datasheet PDF