HDAC3 Antibody

Catalog Number:

31216

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O15347
Gene ID:3149

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 414-428 amino acids of Human histone deacetylase 3

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total HDAC3 protein.

Applications:

ELISA WB

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

References:

appl_detail:

Predicted MW: 49kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF