GNRHR Antibody

Catalog Number:

31212

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8WUI4
Gene ID:51564

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 62-75 amino acids of Human gonadotropin-releasing hormone receptor

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total GNRHR protein.

Applications:

ELISA WB IHC

Background:

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

References:

appl_detail:

Predicted MW: 28kd
ELISA: 1:1000-1:10000
Western blotting: 1:2000-1:5000
Immunohistochemistry: 1:150-1:500

Datasheet PDF