Product Datasheet  
GNRHR Antibody  
Catalog Number: 31212  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q8WUI4
    Gene ID:51564
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 62-75 amino acids of Human gonadotropin-releasing hormone receptor
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Predicted MW: 28kd
    ELISA: 1:1000-1:10000
    Western blotting: 1:2000-1:5000
    Immunohistochemistry: 1:150-1:500

  • other_names：  
  • gonadotropin-releasing hormone receptor, HH7, GRHR, LRHR, LHRHR, GNRHR2
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total GNRHR protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  

  • This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.




 
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