CLDN1 Antibody

Catalog Number:

31203

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O00451
Gene ID:2675

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 196-209 amino acids of Human claudin 1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CLDN1 protein.

Applications:

ELISA WB IHC

Background:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

References:

appl_detail:

Predicted MW: 23kd
ELISA: 1:1000-1:10000
Western blotting: 1:2000-1:5000
Immunohistochemistry: 1:100-1:300

Datasheet PDF