GRPR Antibody

Catalog Number:

31200

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95832
Gene ID:9076

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 350-365 amino acids of Human gastrin-releasing peptide receptor

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total GRPR protein.

Applications:

ELISA WB IHC

Background:

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

References:

appl_detail:

Predicted MW: 43kd
ELISA: 1:1000-1:5000
Western blotting: 1:1000-1:2000
Immunohistochemistry: 1:25-1:100

Datasheet PDF