Product Datasheet  
GRPR Antibody  
Catalog Number: 31200  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:O95832
    Gene ID:9076
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 350-365 amino acids of Human gastrin-releasing peptide receptor
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 43kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:1000-1:2000
    Immunohistochemistry: 1:25-1:100
  • other_names：  
  • gastrin-releasing peptide receptor
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total GRPR protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.



 
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