PVRL1 Antibody

Catalog Number:

31189

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6UWV6
Gene ID:339221

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 472-486 amino acids of Human Poliovirus receptor-related protein 1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PVRL1 protein.

Applications:

ELISA WB

Background:

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

References:

appl_detail:

Predicted MW: 57kd
ELISA: 1:500-1:5000
Western blotting: 1:200-1:1000

Datasheet PDF