Product Datasheet  
PVRL1 Antibody  
Catalog Number: 31189  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q6UWV6
    Gene ID:339221
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 472-486 amino acids of Human Poliovirus receptor-related protein 1
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 57kd
    ELISA: 1:500-1:5000
    Western blotting: 1:200-1:1000
  • other_names：  
  • Poliovirus receptor-related protein 1, ED4, PRR, HIgR, HVEC, OFC7, PRR1, PVRR, CD111, PVRR1, SK-12, CLPED1, nectin-1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total PVRL1 protein.
  • Applications：  
  • ELISA WB
  • Background：  
  • This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.



 
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