EIF4G2 Antibody

Catalog Number:

31184

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P43005
Gene ID:6505

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 796-812 amino acids of Human Eukaryotic translation initiation factor 4 gamma 2

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total EIF4G2 protein.

Applications:

ELISA WB IHC

Background:

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

References:

appl_detail:

Predicted MW: 102kd
ELISA: 1:500-1:5000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:10-1:50

Datasheet PDF