Product Datasheet  
EIF4G2 Antibody  
Catalog Number: 31184  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P43005
    Gene ID:6505
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 796-812 amino acids of Human Eukaryotic translation initiation factor 4 gamma 2
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 102kd
    ELISA: 1:500-1:5000
    Western blotting: 1:200-1:1000
    Immunohistochemistry: 1:10-1:50
  • other_names：  
  • Eukaryotic translation initiation factor 4 gamma 2, P97, AAG1, DAP5, NAT1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total EIF4G2 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.



 
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