CCND2 Antibody

Catalog Number:

31179

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q16531
Gene ID:1642

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 264-279 amino acids of Human cyclin D2

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CCND2 protein.

Applications:

ELISA WB

Background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suY0ressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

References:

appl_detail:

Predicted MW: 33kd
ELISA: 1:1000-1:10000
Western blotting: 1:2000-1:5000

Datasheet PDF