Product Datasheet  
CCND2 Antibody  
Catalog Number: 31179  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q16531
    Gene ID:1642
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 264-279 amino acids of Human cyclin D2
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 33kd
    ELISA: 1:1000-1:10000
    Western blotting: 1:2000-1:5000

  • other_names：  
  • cyclin D2, KIAK0002
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total CCND2 protein.
  • Applications：  
  • ELISA WB
  • Background：  

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suY0ressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.




 
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