CBFA1 Antibody

Catalog Number:

31165

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q99741
Gene ID:990

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 320-336 amino acids of Human Core-binding factor subunit alpha-1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CBFA1 protein.

Applications:

ELISA WB IHC

Background:

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

References:

appl_detail:

Predicted MW: 54kd
ELISA: 1:500-1:5000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:10-1:50

Datasheet PDF