Product Datasheet  
CBFA1 Antibody  
Catalog Number: 31165  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q99741
    Gene ID:990
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 320-336 amino acids of Human Core-binding factor subunit alpha-1
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 54kd
    ELISA: 1:500-1:5000
    Western blotting: 1:200-1:1000
    Immunohistochemistry: 1:10-1:50
  • other_names：  
  • Core-binding factor subunit alpha-1 , CCD, AML3, CCD1, OSF2, OSF-2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total CBFA1 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.



 
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