BBC3 Antibody

Catalog Number:

31161

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P35222
Gene ID:1499

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 180-193 amino acids of Human Bcl-2-binding component 3

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total BBC3 protein.

Applications:

ELISA WB

Background:

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Predicted MW: 21kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF