Product Datasheet  
BBC3 Antibody  
Catalog Number: 31161  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P35222
    Gene ID:1499
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 180-193 amino acids of Human Bcl-2-binding component 3
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 21kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:500-1:2000
  • other_names：  
  • Bcl-2-binding component 3, JFY1, PUMA, JFY-1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total BBC3 protein.
  • Applications：  
  • ELISA WB
  • Background：  
  • This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.



 
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