ACVR2A Antibody

Catalog Number:

31159

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P21781
Gene ID:2252

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 346-363 amino acids of Human Activin receptor type-2A

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total ACVR2A protein.

Applications:

ELISA WB IHC

Background:

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

References:

appl_detail:

Predicted MW: 58kd
ELISA: 1:2000-1:10000
Western blotting: 1:1000-1:2000
Immunohistochemistry: 1:25-1:100

Datasheet PDF