Product Datasheet  
ACVR2A Antibody  
Catalog Number: 31159  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P21781
    Gene ID:2252
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 346-363 amino acids of Human Activin receptor type-2A
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 58kd
    ELISA: 1:2000-1:10000
    Western blotting: 1:1000-1:2000
    Immunohistochemistry: 1:25-1:100
  • other_names：  
  • Activin receptor type-2A, ACVR2, ACTRII
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total ACVR2A protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.



 
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