ALX4 Antibody

Catalog Number:

31157

Amount:

100μg

Price:

$319

Swiss-Prot No:

Genbank No.: NP_068745

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from 27-45 amino acids of Human ALX homeobox 4

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total ALX4 protein.

Applications:

ELISA WB

Background:

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.

References:

appl_detail:

Predicted MW: 44kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:1000

Datasheet PDF