Product Datasheet  
ALX4 Antibody  
Catalog Number: 31157  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Genbank No.: NP_068745
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 27-45 amino acids of Human ALX homeobox 4
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 44kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:500-1:1000
  • other_names：  
  • ALX homeobox 4, FND2
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total ALX4 protein.
  • Applications：  
  • ELISA WB
  • Background：  
  • This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.



 
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