F10 Antibody

Catalog Number:

31132

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P31946
Gene ID:7529

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 235-488 amino acids of human coagulation factor X

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total F10 protein.

Applications:

ELISA WB

Background:

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

References:

appl_detail:

Predicted MW: 55kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:1000

Datasheet PDF