Product Datasheet  
F10 Antibody  
Catalog Number: 31132  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P31946
    Gene ID:7529
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 235-488 amino acids of human coagulation factor X
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 55kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:1000

  • other_names：  
  • Coagulation factor X, FX; FXA
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total F10 protein.
  • Applications：  
  • ELISA WB
  • Background：  

  • This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.




 
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