SPATA13 Antibody

Catalog Number:

31130

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q969V4
Gene ID:83659

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 240-424 amino acids of human spermatogenesis associated 13

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total SPATA13 protein.

Applications:

ELISA WB

Background:

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

References:

appl_detail:

Predicted MW: 75kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:1000

Datasheet PDF