Product Datasheet  
SPATA13 Antibody  
Catalog Number: 31130  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q969V4
    Gene ID:83659
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 240-424 amino acids of human spermatogenesis associated 13
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 75kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:1000

  • other_names：  
  • Spermatogenesis associated 13, ASEF2; ARHGEF29; RP11-307N16.3
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total SPATA13 protein.
  • Applications：  
  • ELISA WB
  • Background：  

  • Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.




 
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