RRM1 Antibody

Catalog Number:

31118

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P05388
Gene ID:6175

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to C terminal 226 amino acids of human ribonucleotide reductase M1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total RRM1 protein.

Applications:

ELISA WB IHC

Background:

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

References:

appl_detail:

Predicted MW: 90kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100

Datasheet PDF