Product Datasheet  
RRM1 Antibody  
Catalog Number: 31118  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P05388
    Gene ID:6175
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to C terminal 226 amino acids of human ribonucleotide reductase M1
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 90kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:1000
    Immunohistochemistry: 1:25-1:100
  • other_names：  
  • Ribonucleotide reductase M1, R1; RR1; RIR1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total RRM1 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.



 
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