PRCP Antibody

Catalog Number:

31116

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O43242
Gene ID:5709

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 46-317 amino acids of human prolylcarboxypeptidase (angiotensinase C)

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PRCP protein.

Applications:

ELISA WB IHC

Background:

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

References:

appl_detail:

Predicted MW: 56kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100

Datasheet PDF