Product Datasheet  
PRCP Antibody  
Catalog Number: 31116  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:O43242
    Gene ID:5709
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 46-317 amino acids of human prolylcarboxypeptidase (angiotensinase C)
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 56kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:1000
    Immunohistochemistry: 1:25-1:100
  • other_names：  
  • Prolylcarboxypeptidase (angiotensinase C), PCP; HUMPCP
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total PRCP protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.



 
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