PIWIL4 Antibody

Catalog Number:

31113

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P42785
Gene ID:5547

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 546-838 amino acids of human piwi-like RNA-mediated gene silencing 4

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PIWIL4 protein.

Applications:

ELISA WB

Background:

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.

References:

appl_detail:

Predicted MW: 97kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF