Product Datasheet  
PIWIL4 Antibody  
Catalog Number: 31113  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P42785
    Gene ID:5547
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 546-838 amino acids of human piwi-like RNA-mediated gene silencing 4
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 97kd
    ELISA: 1:2000-1:5000
    Western blotting: 1:500-1:2000
  • other_names：  
  • Piwi-like RNA-mediated gene silencing 4, HIWI2; MIWI2
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total PIWIL4 protein.
  • Applications：  
  • ELISA WB
  • Background：  
  • PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.



 
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