PC Antibody

Catalog Number:

31111

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P62140
Gene ID:5500

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 563-832 amino acids of human pyruvate carboxylase

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total PC protein.

Applications:

ELISA WB

Background:

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

References:

appl_detail:

Predicted MW: 130kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:1000

Datasheet PDF