Product Datasheet  
PC Antibody  
Catalog Number: 31111  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P62140
    Gene ID:5500
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 563-832 amino acids of human pyruvate carboxylase
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 130kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:1000

  • other_names：  
  • Pyruvate carboxylase, PCB
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total PC protein.
  • Applications：  
  • ELISA WB
  • Background：  

  • This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.




 
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