MCM3 Antibody

Catalog Number:

31099

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q04206
Gene ID:5970

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to C terminal 300 amino acids of human minichromosome maintenance complex component 3

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total MCM3 protein.

Applications:

ELISA WB IHC

Background:

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Predicted MW: 91kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Datasheet PDF