Product Datasheet  
MCM3 Antibody  
Catalog Number: 31099  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q04206
    Gene ID:5970
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to C terminal 300 amino acids of human minichromosome maintenance complex component 3
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 91kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:50-1:200
  • other_names：  
  • minichromosome maintenance complex component 3, HCC5, P1.h, RLFB, P1-MCM3
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total MCM3 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.



 
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