AK1 Antibody

Catalog Number:

31027

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P08133
Gene ID:309

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 1-194 amino acids of Human Adenylate kinase isoenzyme 1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total AK1 protein.

Applications:

ELISA WB IHC

Background:

Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.

References:

appl_detail:

Predicted MW: 22kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:1000
Immunohistochemistry: 1:25-1:100

Datasheet PDF