IL18BP Antibody

Catalog Number:

31022

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95831
Gene ID:9131

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 31-195 of human Interleukin-18-binding protein

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total IL18BP protein.

Applications:

ELISA WB

Background:

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

References:

appl_detail:

Predicted MW: 21kd
ELISA: 1:1000-1:5000
Western blotting: 1:500-1:2000

Datasheet PDF