SMAD4 Antibody

Catalog Number:

31017

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q14626
Gene ID:3590

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 14-227 amino acids of human SMAD family member 4

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total SMAD4 protein.

Applications:

ELISA WB

Background:

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

References:

appl_detail:

Predicted MW: 61kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:500

Datasheet PDF