Product Datasheet  
SMAD4 Antibody  
Catalog Number: 31017  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q14626
    Gene ID:3590
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 14-227 amino acids of human SMAD family member 4
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 61kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:500
  • other_names：  
  • SMAD family member 4, JIP, DPC4, MADH4, MYHRS
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total SMAD4 protein.
  • Applications：  
  • ELISA WB
  • Background：  
  • This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.



 
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